Almost every enemy drops a coin (which vanishes quickly) when killed.
An even easier method to quickly fill up the machine, though it will take a while to unlock, is to use Tainted Keeper. If the Keeper has Swallowed Penny, this will make surviving easier and grant you unlimited coins. Not only can he clear out rooms faster due to his triple shot and above-average damage, he also starts with Wooden Nickel, Store Key, an extra coin provided that you have the required marks completed, and a bomb that can give you access to out-of-reach coins or possible coins in vases, corpses, and slot machines. Assuming the player has enough skill, Keeper is excellent for filling the machine. When the machine jams, simply reset and farm some more. The Donation Machine can be quickly filled using Azazel and farming coins on the first few floors. With the Placenta, a Blood Donation Machine or IV Bag, and a lot of patience, enough money can be generated to jam the machine. Because Humbling Bundle no longer guarantees that every penny is doubled, this method is less effective and can possibly lead to a loss of money. The profit can be used to buy shop items or donate back to the machine until it jams. With the Humbling Bundle, every cent received from bombing the Donation Machine is doubled however, the amount deducted from the Donation Machine is mostly less than what is dropped from it. This will effectively prevent accidental 1000th cent donations. It is recommended to deliberately bomb the Donation Machine such that the banked total is less than 999 cents. Causing the Donation Machine to explode at 1000 cents is not recommended, as it does not unlock anything and removes the ability to trade bombs for coins in future runs until the coin total has been rebuilt back up. Stop Watch - Donate 999 Coins to the Donation Machine. To calculate the odds of the machine not jamming after donations, use the formula 
The maximum amount of coins Isaac can carry with Deep Pockets The amount of coins that can be donated at once with 99 coins and proper usage of a 2 of Diamonds card The maximum amount of coins Isaac can carry without Deep Pockets It is possible for the machine to jam after donating a single coin. The total jam chance is considered the probability of a jam at donating amount of coins.
Donation Machines cannot appear while achievements are disabled.īelow is a table of the expected probabilities that donating any amount of coins will jam the Donation Machine, assuming that every donation has an independent 5% chance to cause a jam. This will not increase the chance to earn a room, it will instead sway the chance of the earned room to be an angel room. Donating ten coins to a Donation Machine will increase the odds of an Angel Room appearing instead of a devil room if you have not taken a devil deal. Donations have a small chance to increase Isaac's luck by 1. 
If Isaac attempts to donate a 1000th coin, the Donation Machine will explode, resetting its total to 0 and dropping roughly 12 dimes.A total of 999 coins can be donated to the Donation Machine.Bombing a Donation Machine yields a larger amount of coins than the figure of ‘ 1-5 pennies’, stated in the parent bullet.Bombing a Donation Machine will destroy it, and no more Donation Machines will appear for the rest of the run the coins it drops will be deducted from the donation total at the start of the next run.The Donation Machine can be bombed until the coin counter displays zero.The Donation Machine will drop coins even when the Donation Machine is jammed.Humbling Bundle causes pennies to instead spawn as double pennies, allowing you to circumvent the above.Because of this, donating dropped pennies back into the Donation Machine generally results in a net decrease in the machine's total.The dropped pennies will be deducted from the total however, the deduction will always be 1 more than the total number of pennies dropped.Bombing the Donation Machine in any way will cause it to drop 1-5 pennies.On average, a Donation Machine will accept 20 coins before jamming on every run.Once the machine is jammed, no more coins can be donated to it until a new run is started. Every donation made to the Donation Machine on a single run has a 5% chance to jam the machine.
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